From Alpha to Omicron BA.2: New digital RT-PCR approach and challenges for SARS-CoV-2 VOC monitoring and normalization of variant dynamics in wastewaterArticle Published on 2022-11-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach circulation Concentration COVID-19 COVID-19 pandemic discrimination Epidemic fecal France Genome sequencing greater human population immune response immunized incidence Local MONITOR New normalization omicron Paris pathogenicity Patient PMMoV populations prevalent proportion public health resulting risk RT-PCR SARS-CoV-2 selection of variant Sequencing Severity of infection specific mutation Spread statistically strain subject suggested the SARS-CoV-2 genome Transmissibility Vaccination strategy Variability variant variants of concern Variation viral dynamics viral spread virus VoC VOCs wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157740 PMC 바로가기
The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6Article Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antibody escape mutation binding binding interaction claimed COVID-19 human population IMPROVE molecular Mutation mutations N501Y Neutralizing antibodies neutralizing antibody pathogen Potential treatment predicted previous study Receptor binding domain responsible resulting S-RBD SARS-CoV-2 severity of COVID-19 the SARS-CoV-2 therapeutic [DOI] 10.1038/s41598-022-23482-5 PMC 바로가기
Genome-wide detection of human variants that disrupt intronic branchpointsArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] Alter approach branchpoint Candidates characterized comparable COVID-19 Critical database demonstrated detect disease Disease genetics disrupt disrupting eight elements enzyme exonic feature heterozygous human gene human population identify initiated intron Intronic intronic variant ITPKB lymphoma machine-learning motif nucleotides upstream pathogenic Patient Pneumonia rare variant reported RNA sequencing RNA splicing sequencing data single-nucleotide Software splicing. STAT2 utility variant variants Variation [DOI] 10.1073/pnas.2211194119 PMC 바로가기
Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African PopulationsArticle Published on 2022-10-142022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Africa African antibody Antigen antigenic Asian blood donor collected control sample coronavirus 2 coronavirus disease-2019 COVID-19 COVID-19 pandemic CoviDiag detect evaluate France French highlighting human population Hypothesis identify IgG Immunity incidence rate investigated morbidity natural immunity neutralizing antibody original antigenic sin. pandemic Population pre-existing immunity Prevalence Protective Region reported respiratory SARS-CoV-2 SARS-CoV-2 protein sera statistically significant difference tested virus West [DOI] 10.3390/v14102259 PMC 바로가기
PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during fluArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] accumulated CD4 Cell characterized co-stimulatory receptor COVID Critical Express expressed flu fluorescent FOXP3 GFP heterogenous human population iCoS IL-10 Immune homeostasis immunopathology in vivo Infection infections Influenza influenza infection influenza infections labeling lung tissue memory T cells molecular feature PD-1 proinflammatory promote Regulatory Regulatory T cell repeated reporter respiratory infectious disease response reveal secondary infections shown Signaling signaling pathway suppress T cell T cell response T cells tissue tissue repair tissue resident T cells. transcription factor Treg Treg cell Treg cells Tuberculosis [DOI] 10.3389/fimmu.2022.984476 PMC 바로가기
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Understanding the mutational frequency in SARS-CoV-2 proteome using structural features구조적 특징을 이용한 SARS-CoV-2 프로테옴의 돌연변이 빈도 이해Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Cluster collected computational approach coronavirus COVID-19 develop Early detection feature Features Frequency human population machine machine learning machine learning model machine learning models mutability mutated Mutation mutations pandemic physicochemical predict Protein Protein mutability proteome provided reduced residue SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2. Sequence conservation severe acute respiratory syndrome Coronavirus severity stability Structural analysis survival the SARS-CoV-2 threshold Transmission understanding unique variants variants of concern viral isolate viral isolates Viral protein viral strains virus virus [DOI] 10.1016/j.compbiomed.2022.105708 PMC 바로가기 [Article Type] Article
Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera중화 혈청에 대한 실험적 노출에 의한 SARS-CoV-2 주요 계통의 돌연변이 유도Article Published on 2022-07-212022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acquisition addition antibody characterisation escape mutation Evolution Evolution of SARS-CoV-2 human population immune evasion immune response Interaction Lineage Mutagenesis neutralisation neutralising neutralising antibody Neutralizing antibody response offer Perspective promoted required responsible SARS-CoV-2 sera species structural protein structural proteins target Viral viral adaptation viral variant [DOI] 10.1038/s41598-022-16533-4 PMC 바로가기 [Article Type] Article
Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trialSARS-CoV-2에 대한 구강청결제 - 시험관 내 막 파괴에 의한 높은 항바이러스 효과는 무작위 위약 대조 임상 시험에서 약한 효과로 해석됩니다.Randomized Controlled Trial Published on 2022-07-152022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Analysis antiseptic Antiseptic agents Antiviral Antiviral effect BAC benzalkonium Benzalkonium chloride can be used capsid Capsid protection assay Cell culture chloride clinical evaluation clinical evaluations COVID-19 disrupting Effect effective intervention evaluated human population in vitro inactivated Infection route Measures membrane Mild minor mouthrinse Mouthwash oral cavity placebo-controlled clinical trial qPCR Randomized reduce reduction respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 subsequent translate Transmission transmission rate transmission rates Treatment variety viral envelope Viral load viral loads Viral RNA virus was used without affecting [DOI] 10.1016/j.virusres.2022.198791 PMC 바로가기 [Article Type] Randomized Controlled Trial
Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning표면 강화 라만 산란 및 기계 학습의 조합을 통해 SARS-CoV-2 변이체와 DNA 프로브의 돌연변이 독립적 상호작용 조사Article Published on 2022-07-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigenicity antisense Antisense oligonucleotide Antisense oligonucleotides ASO binding efficiency Characteristics characterized clinically Combination Concentration coronavirus described detect develop diagnostic diagnostic test DNA Evolution Genetic human population hypothetical Immune profile independent Interaction mechanism mutate Mutation Mutation resistant probe mutations N gene negative sample nucleocapsid Nucleocapsid phosphoprotein Point mutation positive probe probes Probing reveal RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus scattering Selective and ultrasensitive diagnosis sensitivity sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity surface-Enhanced Raman scattering. technique the SARS-CoV-2 virus therapeutic Transmissibility unique variants virus [DOI] 10.1016/j.bios.2022.114200 PMC 바로가기 [Article Type] Article